Description

1-(Trimethylsilyl)Pyrrolidine is a versatile organosilicon compound, specifically a silylated amine, that serves as a valuable reagent and protecting group in advanced organic synthesis. Its primary value lies in its ability to act as a base and a silylating agent, facilitating reactions that are sensitive to moisture or require specific steric and electronic control. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to synthesize complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Synthesis: Key intermediate and protecting group reagent in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the manufacture of advanced pesticides, herbicides, and plant growth regulators requiring specific silicon-containing functionalities.
• Organometallic Chemistry: Acts as a ligand or precursor in the preparation of catalysts and other organometallic complexes.
• Polymer & Material Science: Employed as a monomer or modifying agent in the synthesis of specialty silicones, siloxanes, and other advanced polymeric materials.
• Chemical Research & Development: A crucial reagent in academic and industrial R&D labs for exploring new synthetic methodologies, particularly in nucleophilic substitution and deprotonation reactions.
• Protecting Group Strategy: Utilized to temporarily protect amine functionalities during complex synthetic sequences, enabling selective reactions at other sites on the molecule.

Basic Information

Product Name	1-(Trimethylsilyl)Pyrrolidine
CAS No.	15097-49-1
Molecular Formula	C7H17NSi
Molecular Weight	143.30 g/mol
Synonyms	N-(Trimethylsilyl)pyrrolidine; Pyrrolidine, 1-(trimethylsilyl)-; Trimethylsilylpyrrolidine; N-Trimethylsilylpyrrolidine; 1-Trimethylsilylpyrrolidine; TMS-Pyrrolidine; N-TMS-pyrrolidine
EINECS	239-147-7

Quality Control

Our 1-(Trimethylsilyl)Pyrrolidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reliable and reproducible performance in sensitive synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.