Description

3-Oxo-7α,12α-Bis(trimethylsilyloxy)-5α-cholan-24-oic acid methyl ester is a key protected intermediate in the synthesis of bile acids and their derivatives. This compound is critical for researchers and manufacturers requiring high-purity, structurally defined precursors for pharmaceutical development and biochemical research. It is primarily utilized by the pharmaceutical, biotechnology, and fine chemical industries for the production of steroid-based therapeutics and advanced research reagents.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of therapeutic bile acids and their analogs.
• Steroid Chemistry Research: Used in academic and industrial laboratories for studying steroid metabolism and developing novel steroid-based compounds.
• Biochemical Probe Synthesis: Serves as a precursor for labeled (e.g., deuterated, fluorinated) bile acid derivatives used in metabolic studies.
• Fine Chemical Production: Employed in the manufacture of high-value, specialized chemicals for diagnostic and research applications.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in related API manufacturing.

Basic Information

Item	Details
Product Name	3-Oxo-7α,12α-Bis(trimethylsilyloxy)-5α-cholan-24-oic acid methyl ester
CAS No.	15093-98-8
Molecular Formula	C31H56O5Si2
Molecular Weight	564.94 g/mol
Synonyms	Methyl 3-oxo-7α,12α-bis(trimethylsilyloxy)-5α-cholan-24-oate; 7α,12α-Bis-O-(trimethylsilyl)-3-oxo-5α-cholan-24-oic Acid Methyl Ester; 3-Oxo-7α,12α-bis[(trimethylsilyl)oxy]-5α-cholan-24-oic Acid Methyl Ester; Methyl 3-keto-7α,12α-bis(trimethylsiloxy)-5α-cholan-24-oate; Protected Methyl Deoxycholate Derivative; TMS-protected bile acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Oxo-7α,12α-Bis(trimethylsilyloxy)-5α-cholan-24-oic acid methyl ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for research and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.