Description

(Chloro)[2-(Chloroformyl)Ethyl](Methyl)Phosphine Oxide is a specialized organophosphorus compound that serves as a versatile intermediate in advanced chemical synthesis. Its unique bifunctional structure, featuring both a phosphine oxide and an acid chloride group, makes it a valuable precursor for constructing complex molecules and functional materials. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in ligand synthesis, catalyst development, and the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting neurological pathways.
• Agrochemical Synthesis: Used in the production of advanced herbicides, insecticides, and plant growth regulators.
• Ligand & Catalyst Precursor: Serves as a starting material for synthesizing specialized phosphine-based ligands used in homogeneous catalysis (e.g., cross-coupling reactions).
• Polymer Modification: Employed to introduce phosphine oxide functionalities into polymer backbones to enhance flame retardancy or thermal stability.
• Material Science Research: Utilized in the development of advanced materials, including metal-organic frameworks (MOFs) and functional coatings.
• Chemical Biology Probes: Acts as a reactive handle for creating probes that study phosphoprotein interactions and signaling pathways.

Basic Information

Product Name	(Chloro)[2-(Chloroformyl)Ethyl](Methyl)Phosphine Oxide
CAS No.	15090-24-1
Molecular Formula	C4H7Cl2O2P
Molecular Weight	189.97 g/mol
Synonyms	2-(Chloroformyl)ethyl(methyl)phosphinic chloride; 3-Chloro-2-oxo-2-[(methylphosphinoyl)chlorido]ethyl chloride; Methyl(3-chloro-2-oxopropanoyl)phosphinic chloride; (Chloro){2-[(chlorocarbonyl)oxy]ethyl}(methyl)phosphine oxide; (Methyl)[2-(chloroformyl)ethyl]chlorophosphine oxide; β-Chlorocarbonylethyl methylphosphinic chloride
EINECS	Contact for details

Quality Control

Our (Chloro)[2-(Chloroformyl)Ethyl](Methyl)Phosphine Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment to cGMP and ISO standards ensures reliable supply for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.