Description

Brusatol is a potent quassinoid compound, a natural product derived from the Brucea javanica plant. This bioactive molecule is a subject of significant research interest due to its role as a selective inhibitor of Nrf2 signaling, a key pathway in cellular stress response and oncogenesis. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for advanced drug discovery and mechanistic studies in areas such as oncology, chemoresistance, and cytoprotection.

Application

• Pharmaceutical Research & Drug Discovery: A critical tool for investigating the Nrf2 pathway's role in cancer cell proliferation, metastasis, and resistance to chemotherapy and radiotherapy.
• Biochemical & Molecular Biology Studies: Used as a selective probe to elucidate mechanisms of oxidative stress response, autophagy, and apoptosis in various cell lines.
• Preclinical Development: Serves as a lead compound or a reference standard in the development of novel therapeutic agents targeting Nrf2 for cancer treatment.
• Natural Product & Phytochemistry Research: Studied for its isolation, structural activity relationships (SAR), and as a marker compound for quality control of Brucea javanica extracts.
• Academic Research: Employed in university and institutional labs for fundamental research into cell signaling pathways and natural product pharmacology.

Basic Information

Product Name	Brusatol
CAS No.	14907-98-3
Molecular Formula	C₂₆H₃₂O₁₁
Molecular Weight	520.53 g/mol
Synonyms	Brusatol; (3aS,4R,5S,6aR,7R,8S,9aR,9bS)-4,5,7,8,13,14,15-Heptahydroxy-4,6a,9a,9b-tetramethyl-2,10-dioxo-2,3,3a,4,5,6,6a,7,8,9,9a,9b,10,11-tetradecahydro-1H-cyclopenta[a]cyclopropa[f]cycloundecen-11-yl (2E)-2-methylbut-2-enoate; Bruceantin analog; NSC 172924
EINECS	Contact for details

Quality Control

Our Brusatol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support research standards and can provide material for use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95%
Loss on Drying	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.