Description

5-(Bromoacetyl)-3-Phenylisoxazole CAS NO 14731-14-7 is a versatile and highly functionalized heterocyclic building block, specifically an isoxazole derivative bearing a reactive bromoacetyl group. This compound is of significant value in synthetic organic and medicinal chemistry due to its dual functionality, allowing for selective modifications at both the isoxazole ring and the bromoacetyl side chain. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures, including potential drug candidates and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel bioactive molecules, particularly in the synthesis of potential kinase inhibitors, anti-inflammatory agents, and other therapeutic compounds targeting the isoxazole pharmacophore.
• Agrochemical Research: Used in the design and synthesis of new generation herbicides, fungicides, and insecticides, leveraging the isoxazole moiety for enhanced biological activity.
• Chemical Biology & Proteomics: The reactive bromoacetyl group serves as an effective electrophile for bioconjugation, enabling the labeling or cross-linking of proteins, peptides, and other biomolecules for study.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the synthesis of specialized polymers and functional organic materials with tailored optical or electronic properties.
• Academic & Contract Research: Essential for methodological development in organic synthesis, including cycloaddition reactions and palladium-catalyzed cross-coupling processes.

Basic Information

Product Name	5-(Bromoacetyl)-3-Phenylisoxazole
CAS No.	14731-14-7
Molecular Formula	C11H8BrNO2
Molecular Weight	266.09 g/mol
Synonyms	3-Phenyl-5-(bromoacetyl)isoxazole; 5-Bromoacetyl-3-phenylisoxazole; 1-(3-Phenylisoxazol-5-yl)-2-bromoethanone; 2-Bromo-1-(3-phenyl-1,2-oxazol-5-yl)ethan-1-one; Bromoacetylphenylisoxazole; α-Bromo-3-phenylisoxazole-5-acetophenone
EINECS	Contact for details

Quality Control

Our 5-(Bromoacetyl)-3-Phenylisoxazole is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) specifying batch-specific results for identity, purity, and impurities is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.