Description

(E)-4-[(2,5-Dioxocyclopentyl)Amino]-4-Oxo-2-Butenoic Acid Methyl Ester is a high-purity, functionalized chemical intermediate with a reactive maleimide moiety. This compound is valued for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for applications in bioconjugation and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and antibody-drug conjugates (ADCs).
• Bioconjugation Reagent: Used to covalently link therapeutic payloads, such as cytotoxic drugs or imaging agents, to targeting molecules like antibodies or peptides via its maleimide group.
• Proteomics Research: Employed in the labeling and modification of proteins and peptides for analytical and diagnostic purposes.
• Polymer Chemistry: Serves as a functional monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Chemical Biology Tool: Utilized in the development of chemical probes to study biological pathways and protein function.
• Material Science: Applied in the surface functionalization of nanomaterials and biosensors to enhance specificity and performance.

Basic Information

Product Name	(E)-4-[(2,5-Dioxocyclopentyl)Amino]-4-Oxo-2-Butenoic Acid Methyl Ester
CAS No.	14670-20-3
Molecular Formula	C10H11NO6
Molecular Weight	241.20 g/mol
Synonyms	N-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methoxy-3-oxoprop-1-en-1-amine; Methyl (2E)-4-[(2,5-dioxo-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoate; Maleimidopropionic Acid Methyl Ester; 3-Maleimidopropionic Acid Methyl Ester; Methyl 3-Maleimidopropionate; N-Maleoyl-β-alanine Methyl Ester; (E)-Methyl 4-((2,5-dioxocyclopentyl)amino)-4-oxobut-2-enoate
EINECS	Contact for details

Quality Control

Our (E)-4-[(2,5-Dioxocyclopentyl)Amino]-4-Oxo-2-Butenoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.