Description

2-Cyanotetrahydrofuran is a versatile heterocyclic nitrile compound that serves as a critical building block in advanced organic synthesis. Its value lies in its bifunctional structure, combining a reactive nitrile group with a tetrahydrofuran ring, enabling its use in the construction of complex pharmaceutical intermediates and fine chemicals. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable and scalable synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing pyrrolidine or other N-heterocycles.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require tetrahydrofuran-based architectures.
• Fine Chemical Building Block: Employed in the manufacture of specialty chemicals, including dyes, pigments, and complex ligands for catalysis.
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialized polymers and resins with unique properties.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel compound libraries.
• Nitrile Transformation Chemistry: Serves as a substrate for reactions such as hydrolysis to amides/acids, reduction to amines, or cycloadditions.

Basic Information

Product Name	2-Cyanotetrahydrofuran
CAS No.	14631-43-7
Molecular Formula	C5H7NO
Molecular Weight	97.12 g/mol
Synonyms	2-Cyanotetrahydrofuran; Tetrahydro-2-furancarbonitrile; 2-Furancarbonitrile, tetrahydro-; 2-Tetrahydrofurancarbonitrile; α-Cyanotetrahydrofuran; NSC 163045; 2-Cyanotetrahydrofuran (stabilized with TBC)
EINECS	238-661-5

Quality Control

Our 2-Cyanotetrahydrofuran is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including GC and HPLC, to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Refractive Index (n20D)	1.4400 - 1.4450
Density (g/mL at 20°C)	1.010 - 1.030

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.