Description

Bis(Trimethylsilyl)Acetylene (CAS NO 14630-40-1) is a highly versatile organosilicon reagent featuring a protected acetylene unit. This compound is a critical building block in organic synthesis, valued for its ability to introduce the trimethylsilyl-protected ethynyl group under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing alkyne-containing molecular scaffolds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the acetylene moiety is a core structural element.
• Material Science: Serves as a precursor for silicon-containing polymers, dendrimers, and other advanced organic materials.
• Cross-Coupling Reactions: An essential substrate in Sonogashira, Glaser, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Organic Synthesis Reagent: Employed as a protected acetylene equivalent in multi-step syntheses, offering stability and selective deprotection.
• Ligand and Catalyst Development: Used to synthesize novel ligands and organometallic complexes for catalytic applications.

Basic Information

Product Name	Bis(Trimethylsilyl)Acetylene
CAS No.	14630-40-1
Molecular Formula	C8H18Si2
Molecular Weight	170.40 g/mol
Synonyms	1,2-Bis(trimethylsilyl)acetylene; BTMSA; Hexamethyl-1,2-ethynylenedisilane; Ethyne, 1,2-bis(trimethylsilyl)-; 1,2-Bis(trimethylsilyl)ethyne; TMS-acetylene-TMS; (Trimethylsilyl)ethynyltrimethylsilane
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl)Acetylene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC and NMR analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat, sparks, and open flame. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.