Description

Trimethylsilyl-D(+)Mannitol is a silylated derivative of D-mannitol, a key chiral building block and protecting group reagent in advanced organic synthesis. This compound is valued for its ability to impart volatility and modify the solubility of mannitol-based intermediates, facilitating purification and analysis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex, optically active molecules.

Application

• Pharmaceutical Intermediate: Serves as a chiral precursor or protected intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring mannitol-derived stereocenters.
• Gas Chromatography (GC) Derivatization: Used to derivative D-mannitol and related polyols for analysis by GC or GC-MS, improving their thermal stability and volatility.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective reactions to construct molecules with defined optical activity.
• Protecting Group Chemistry: The trimethylsilyl (TMS) groups protect hydroxyl functionalities during multi-step synthetic sequences, which can be removed under mild conditions.
• Material Science Research: Investigated for modifying surface properties or creating silylated polymers and dendrimers with specific hydrophilic/hydrophobic balances.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and verification in chiral analysis.

Basic Information

Product Name	Trimethylsilyl-D(+)Mannitol
CAS No.	14317-07-8
Molecular Formula	C15H38O6Si3
Molecular Weight	398.71 g/mol
Synonyms	1,2,3,4,5,6-Hexakis-O-(trimethylsilyl)-D-mannitol; D-Mannitol, hexakis(trimethylsilyl) ether; Hexakis(trimethylsilyl)mannitol; D-Mannitol per(trimethylsilyl) ether; TMS-D-Mannitol; TMS-Mannitol; Trimethylsilyl ether of D-mannitol; D-Mannitol hexa(trimethylsilyl) derivative
EINECS	Contact for details

Quality Control

Our Trimethylsilyl-D(+)Mannitol is produced under a strict quality management system. Each batch is characterized and tested to ensure identity, purity, and chiral integrity, meeting the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing purity (typically by GC or HPLC), specific rotation, and other critical parameters are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 95.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.