Description

1,4-Dihydro-1,2,4,6-Tetramethyl-3,5-Pyridinedicarboxylic Acid Diethyl Ester is a high-purity, versatile Hantzsch ester derivative, serving as a critical intermediate in advanced organic synthesis. Its core value lies in its role as a potent and selective hydrogen atom transfer (HAT) reagent and a versatile building block for constructing complex nitrogen-containing heterocycles. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, where it enables key synthetic transformations under mild conditions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of dihydropyridine (DHP) calcium channel blockers and other active pharmaceutical ingredients (APIs).
• Organic Synthesis Reagent: Employed as a mild and efficient hydrogen source in reductive dehalogenation, deoxygenation, and other radical-mediated reactions.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging its heterocyclic core structure.
• Fine Chemical Building Block: For constructing complex molecular architectures in materials science and specialty chemistry applications.
• Research & Development: A valuable tool in methodological development for photoredox catalysis and sustainable chemistry protocols.
• Ligand and Catalyst Precursor: Can be modified to create novel ligands for metal complexes used in catalytic processes.

Basic Information

Product Name	1,4-Dihydro-1,2,4,6-Tetramethyl-3,5-Pyridinedicarboxylic Acid Diethyl Ester
CAS No.	14258-08-3
Molecular Formula	C16H25NO4
Molecular Weight	295.37 g/mol
Synonyms	Hantzsch Ester, DEADH; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1,2,4,6-tetramethyl-, diethyl ester; Diethyl 1,4-dihydro-1,2,4,6-tetramethyl-3,5-pyridinedicarboxylate; 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester; Diethyl Hantzsch Ester; Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid diethyl ester; Ethyl Hantzsch Ester; 1,4-DHP Derivative
EINECS	Contact for details

Quality Control

Our 1,4-Dihydro-1,2,4,6-Tetramethyl-3,5-Pyridinedicarboxylic Acid Diethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and batch-to-batch consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.