Description

Cyclobutanol, 3-Amino-2,2,4,4-Tetramethyl- is a highly functionalized, sterically hindered cyclobutane derivative that serves as a valuable chiral building block and intermediate in advanced organic synthesis. Its unique structure, featuring a strained four-membered ring with amino and hydroxyl substituents, is critical for constructing complex molecular architectures with specific stereochemistry. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-infectives.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where its rigid cyclobutane core can impart unique biological activity and metabolic stability.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of specialized chiral ligands used in asymmetric catalysis (e.g., hydrogenation, cross-coupling).
• Advanced Material Monomer: Potential monomer for creating polymers with unique thermal and mechanical properties due to the strained ring structure.
• Academic & R&D: A valuable tool compound in organic chemistry research for studying ring strain, stereoselective reactions, and the synthesis of complex natural product analogs.

Basic Information

Item	Details
Product Name	Cyclobutanol, 3-Amino-2,2,4,4-Tetramethyl-
CAS No.	14241-17-9
Molecular Formula	C8H17NO
Molecular Weight	143.23 g/mol
Synonyms	3-Amino-2,2,4,4-tetramethylcyclobutanol; 2,2,4,4-Tetramethyl-3-aminocyclobutanol; 3-Amino-2,2,4,4-tetramethylcyclobutan-1-ol; Tetramethylaminocyclobutanol; 1-Cyclobutanol, 3-amino-2,2,4,4-tetramethyl-
EINECS	Contact for details

Quality Control

Our Cyclobutanol, 3-Amino-2,2,4,4-Tetramethyl- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 standards for research and development materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the presence of amino and hydroxyl groups, the material may be hygroscopic and should be handled under an inert atmosphere for long-term storage to prevent oxidation or moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.