Description

3-Chloroisothiazole is a versatile halogenated heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its reactivity, serving as a key precursor for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for constructing isothiazole-based scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the isothiazole moiety imparts specific biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Chemical Synthesis: Employed in organic chemistry research for cyclization reactions, cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), and as a substrate for further functionalization.
• Dye and Pigment Industry: Acts as an intermediate in the synthesis of complex heterocyclic dyes and organic pigments.

Basic Information

Product Name	3-Chloroisothiazole
CAS No.	14217-66-4
Molecular Formula	C3H2ClNS
Molecular Weight	119.57 g/mol
Synonyms	3-Chloro-1,2-thiazole; 3-Chloro-δ2-isothiazoline; Isothiazole, 3-chloro-; 3-Chloroisothiazole; 3-Chloro-1,2-thiazole
EINECS	Contact for details

Quality Control

Our 3-Chloroisothiazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its reactive nature, it should be stored separately from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.