Description

4-Bromocrotonic Acid is a versatile halogenated carboxylic acid derivative that serves as a key synthetic intermediate in advanced organic chemistry. Its value lies in its reactive bromine and acid functionalities, enabling it to act as a crucial building block for constructing complex molecular architectures. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly those requiring bromo-alkene or α,β-unsaturated acid moieties.
• Agrochemical Synthesis: Serves as a precursor for creating herbicides, fungicides, and plant growth regulators with specific halogenated side chains.
• Organic Synthesis Building Block: Employed in Michael addition reactions, nucleophilic substitution, and cyclization reactions to form heterocyclic compounds.
• Material Science Research: Utilized in the development of specialty polymers, liquid crystals, and organic electronic materials where bromine acts as a functional handle.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Heck, Suzuki, or Sonogashira couplings for carbon-carbon bond formation.
• Bioconjugation & Labeling: The reactive bromoalkene group can be used for modifying peptides, proteins, or other biomolecules in biochemical research.

Basic Information

Product Name	4-Bromocrotonic Acid
CAS No.	13991-36-1
Molecular Formula	C4H5BrO2
Molecular Weight	164.99 g/mol
Synonyms	(E)-4-Bromobut-2-enoic Acid; trans-4-Bromocrotonic Acid; 4-Bromo-2-butenoic Acid; (E)-4-Bromo-2-butenoic Acid; Crotonic Acid, 4-bromo-; 2-Butenoic acid, 4-bromo-, (E)-; β-Bromocrotonic Acid
EINECS	Contact for details

Quality Control

Our 4-Bromocrotonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its acidic nature, store separately from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	85 - 89 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.