Description

3-Chloro-2-Hydroxy-2-Methyl-Propanoic Acid is a versatile chlorinated hydroxy acid derivative that serves as a key building block in advanced organic synthesis. Its unique structure, featuring both a chloro and a hydroxy group on a tertiary carbon, makes it a valuable intermediate for introducing functional complexity. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical sectors. It is used in the synthesis of active ingredients and other fine chemicals where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring chlorinated or hydroxy-substituted moieties.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators, leveraging its reactive sites for constructing bioactive molecules.
• Ligand and Catalyst Development: Serves as a starting material for creating chiral ligands or metal-organic complexes used in asymmetric catalysis.
• Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce polar chloro and hydroxy groups into polymer chains, altering material properties.
• Organic Synthesis Building Block: Employed in multi-step synthetic routes for constructing complex natural products or other specialty organic compounds.
• Bioconjugation Chemistry: Potential use in modifying biomolecules due to its reactive functional groups that can be selectively transformed.

Basic Information

Product Name	3-Chloro-2-Hydroxy-2-Methyl-Propanoic Acid
CAS No.	13881-41-9
Molecular Formula	C4H7ClO3
Molecular Weight	138.55 g/mol
Synonyms	2-Methyl-3-chloro-2-hydroxypropanoic acid; 3-Chloro-2-hydroxy-2-methylpropionic acid; 2-Hydroxy-2-methyl-3-chloropropanoic acid; 3-Chloro-2-hydroxyisobutyric acid; Chlorohydroxymethylpropanoic acid; α-Hydroxy-β-chloroisobutyric acid; 13881-41-9; NSC 163082
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-2-Hydroxy-2-Methyl-Propanoic Acid adheres to stringent in-process controls and final batch testing to ensure consistent purity and performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the exacting standards required for pharmaceutical and fine chemical intermediates, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which can affect product quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.