Description

Ethyl 4-Phthalimidoacetoacetate is a high-purity, versatile organic intermediate characterized by its phthalimide and acetoacetate functional groups. This compound is critical for the synthesis of complex molecules, offering a reactive handle for constructing heterocyclic and pharmaceutical scaffolds. It is primarily sought by research and development laboratories, fine chemical manufacturers, and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs) and advanced organic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing heterocyclic structures like quinolones or fused ring systems.
• Organic Synthesis Reagent: Used in multi-step synthetic routes for constructing complex organic molecules in academic and industrial research settings.
• Agrochemical Research: Serves as a precursor in the development of novel pesticides and herbicides, leveraging its reactive β-ketoester moiety.
• Material Science: Potential use as a monomer or cross-linking agent in the development of specialized polymers and advanced materials.
• Chemical Biology Probes: Can be utilized to synthesize probes for studying enzymatic activity or protein interactions.

Basic Information

Product Name	Ethyl 4-Phthalimidoacetoacetate
CAS No.	13855-80-6
Molecular Formula	C₁₄H₁₃NO₅
Molecular Weight	275.26 g/mol
Synonyms	Ethyl (4-phthalimido)acetoacetate; Ethyl 2-(1,3-Dioxoisoindolin-2-yl)acetoacetate; 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutanoic Acid Ethyl Ester; Acetoacetic Acid, (o-Carboxybenzamido)-, Ethyl Ester; N-(Carboxyethyl acetoacetyl)phthalimide; Ethyl 4-Phthalimidoacetoacetate; EPAA; 13855-80-6
EINECS	Contact for details

Quality Control

Our Ethyl 4-Phthalimidoacetoacetate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. For customers with specific regulatory needs, we can support documentation for cGMP, ISO, or other quality standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept away from strong oxidizing agents and moisture. For long-term storage, consider using an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108°C - 112°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.