Description

Phenyl(Trimethylsilylethynyl) Ketone is a specialized organosilicon building block featuring a ketone group and a trimethylsilyl-protected alkyne moiety. This unique structure makes it a versatile intermediate for advanced organic synthesis, particularly in the construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D and fine chemical sectors for developing new active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon in the synthesis of complex drug candidates, particularly those requiring alkyne or ketone functional group manipulation.
• Organic Synthesis Building Block: Used in Sonogashira coupling and other cross-coupling reactions to introduce acetylene units into aromatic systems.
• Material Science Research: Precursor for the development of novel organic electronic materials and polymers with tailored properties.
• Agrochemical Synthesis: Intermediate in the creation of advanced crop protection agents with specific bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological studies and exploring new synthetic pathways in laboratory settings.

Basic Information

Product Name	Phenyl(Trimethylsilylethynyl) Ketone
CAS No.	13829-77-1
Molecular Formula	C12H14OSi
Molecular Weight	202.33 g/mol
Synonyms	1-Phenyl-2-(trimethylsilyl)ethynyl ketone; (Trimethylsilyl)ethynyl phenyl ketone; Benzoyl(trimethylsilyl)acetylene; Phenyl(trimethylsilylethynyl)methanone; 2-(Trimethylsilyl)ethynyl phenyl ketone; α-(Trimethylsilylethynyl)acetophenone; TMS-acetylene benzophenone derivative
EINECS	Contact for details

Quality Control

Our Phenyl(Trimethylsilylethynyl) Ketone is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.