Description

n-(4-Aminobenzoyl)-L-Glutamic Acid Diethyl Ester is a high-purity, protected amino acid derivative of significant value in advanced organic synthesis. This compound serves as a critical building block for the preparation of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of targeted therapeutics and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of folate analogs, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected glutamic acid derivative in solid-phase and solution-phase peptide chemistry to construct specific peptide sequences.
• Bioconjugation: Serves as a linker molecule for attaching functional groups, dyes, or drugs to proteins, antibodies, or other biomolecules.
• Chemical Biology Research: Employed in the development of chemical probes and tools to study biological pathways and enzyme functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in the custom synthesis of complex organic molecules.
• Academic Research: Utilized in university and institutional labs for methodological development in organic chemistry and medicinal chemistry projects.

Basic Information

Product Name	n-(4-Aminobenzoyl)-L-Glutamic Acid Diethyl Ester
CAS No.	13726-52-8
Molecular Formula	C16H22N2O5
Molecular Weight	322.36 g/mol
Synonyms	L-Glutamic acid, N-[4-(aminocarbonyl)phenyl]-, 1,5-diethyl ester; Diethyl N-(4-aminobenzoyl)-L-glutamate; 4-Aminobenzoyl-L-glutamic Acid Diethyl Ester; PGAEE; N-(p-Aminobenzoyl)-L-glutamic Acid Diethyl Ester; ABG-DEE; Folate Synthesis Intermediate
EINECS	Contact for details

Quality Control

Our n-(4-Aminobenzoyl)-L-Glutamic Acid Diethyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with major regulatory frameworks including REACH and can provide materials suitable for use under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range available on COA
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.