Description

3-Chloro-4-Methoxybenzyl Chloride is a versatile and reactive benzyl chloride derivative, serving as a critical bifunctional building block in advanced organic synthesis. Its value lies in providing both a reactive chloromethyl group and a substituted aromatic ring, enabling the construction of complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted benzyl moiety.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the chloromethoxybenzyl structure is integral to biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Dye and Pigment Manufacturing: Intermediate for creating complex aromatic compounds used in high-performance dyes and organic pigments.
• Polymer Modification: Employed to introduce functional groups into polymer chains, altering material properties for specialty plastics and resins.
• Cross-coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions, such as Suzuki and Heck reactions, for carbon-carbon bond formation.

Basic Information

Product Name	3-Chloro-4-Methoxybenzyl Chloride
CAS No.	13719-57-8
Molecular Formula	C8H8Cl2O
Molecular Weight	191.06 g/mol
Synonyms	1-(Chloromethyl)-3-chloro-4-methoxybenzene; 3-Chloro-4-methoxybenzyl chloride; 3-Chloro-p-anisyl chloride; 4-Methoxy-3-chlorobenzyl chloride; (3-Chloro-4-methoxyphenyl)methyl chloride; α,3-Dichloro-4-methoxytoluene; NSC 403108
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Methoxybenzyl Chloride is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.30 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.