Description

Proline, 4-Ethoxy-1-Methyl-, L-cis- (8Ci) is a specialized, high-purity derivative of the amino acid proline, characterized by its unique ethoxy and methyl substitutions on the pyrrolidine ring. This compound matters as a sophisticated chiral building block and intermediate, offering precise stereochemical control for the synthesis of complex bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry, peptide mimetic development, and the creation of novel agrochemicals and catalysts.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics & Drug Design: Used to construct non-natural amino acid residues that enhance the metabolic stability, bioavailability, and binding affinity of peptide-based drug candidates.
• Asymmetric Catalysis: Acts as a precursor for chiral ligands or organocatalysts used in stereoselective synthetic transformations.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, or plant growth regulators with specific chiral activity.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to probe biological mechanisms and pathways.
• Fine Chemical Synthesis: Functions as a specialized intermediate for the production of complex, high-value chemicals for various industrial research applications.

Basic Information

Product Name	Proline, 4-Ethoxy-1-Methyl-, L-cis- (8Ci)
CAS No.	13500-59-9
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	L-cis-4-Ethoxy-1-methylproline; (2S,4S)-4-Ethoxy-1-methylpyrrolidine-2-carboxylic acid; 1-Methyl-4-ethoxy-L-proline; 4-Ethoxy-1-methyl-L-proline; cis-4-Ethoxy-1-methylproline; 4-Ethoxy-1-methyl-(2S,4S)-proline; Proline, 4-ethoxy-1-methyl-, L-cis-
EINECS	Contact for details

Quality Control

Our Proline, 4-Ethoxy-1-Methyl-, L-cis- (8Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.