Description

5-Fluoro-1,3-Benzoxazol-2(3H)-One is a versatile fluorinated heterocyclic building block of significant importance in modern synthetic chemistry. Its core value lies in its role as a key intermediate for constructing more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is essential for research and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine atoms into benzoxazole-based scaffolds to modulate biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances bioavailability and environmental stability.
• Material Science Research: Serves as a building block for creating novel fluorinated polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	5-Fluoro-1,3-Benzoxazol-2(3H)-One
CAS No.	13451-79-1
Molecular Formula	C7H4FNO2
Molecular Weight	153.11 g/mol
Synonyms	5-Fluorobenzoxazol-2(3H)-one; 2-Hydroxy-5-fluorobenzoxazole; 5-Fluoro-2-benzoxazolinone; 5-Fluoro-2-hydroxybenzoxazole; 5-Fluoro-1,3-benzoxazol-2-ol; 5-Fluoro-2(3H)-benzoxazolone; 5-Fluoro-2-benzoxazolinone; 5-Fluoro-2-oxo-2,3-dihydrobenzoxazole
EINECS	Contact for details

Quality Control

Our production of 5-Fluoro-1,3-Benzoxazol-2(3H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. We offer material suitable for research and industrial use, with standard purity grades typically exceeding 97% (HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. For advanced applications, we can supply material under controlled conditions to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.