Description

1,1-Difluoro-2-Phenyl-Cyclopropane is a specialized fluorinated cyclopropane derivative, a valuable building block in advanced organic synthesis. Its unique structure, featuring a strained three-membered ring and fluorine atoms, makes it a critical intermediate for introducing fluorinated cyclopropyl motifs into target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorinated cyclopropyl group can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty polymers and advanced materials with unique surface properties or chemical resistance.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Fluorine Chemistry Research: A valuable substrate for studying cyclopropane ring-opening reactions and fluorine-specific transformations in academic and industrial R&D settings.

Basic Information

Product Name	1,1-Difluoro-2-Phenyl-Cyclopropane
CAS No.	13343-40-3
Molecular Formula	C9H8F2
Molecular Weight	154.16 g/mol
Synonyms	1,1-Difluoro-2-phenylcyclopropane; 2-Phenyl-1,1-difluorocyclopropane; Benzene, (1,1-difluorocyclopropyl)-; (1,1-Difluorocyclopropyl)benzene; α,α-Difluoro-β-phenylcyclopropane; Difluorophenylcyclopropane
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-2-Phenyl-Cyclopropane is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity and purity against established specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed and stored upright. Keep away from heat, sparks, and open flame. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.