Description

2-Hydroxy-2-(2-Nitrophenyl)Acetonitrile is a versatile nitrophenyl-substituted cyanohydrin building block of significant interest in synthetic organic chemistry. Its molecular structure, featuring both a reactive nitrile and a hydroxyl group adjacent to an aromatic nitro moiety, makes it a valuable precursor for the synthesis of complex heterocycles and pharmaceutical intermediates. This compound is primarily sought by research and development chemists in the fine chemical, agrochemical, and pharmaceutical industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing quinoline, isoquinoline, or other fused nitrogen heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its nitroaromatic functionality.
• Fine Chemical Building Block: Employed in academic and industrial R&D for the construction of complex organic molecules, dyes, and functional materials.
• Ligand and Catalyst Development: Serves as a precursor for chelating ligands or organocatalysts due to its potential donor atoms (O, N from the nitrile).
• Chemical Research: Utilized in methodological studies for reactions like Henry reactions, cyclizations, and nucleophilic additions involving cyanohydrins.

Basic Information

Product Name	2-Hydroxy-2-(2-Nitrophenyl)Acetonitrile
CAS No.	13312-81-7
Molecular Formula	C8H6N2O3
Molecular Weight	178.15 g/mol
Synonyms	2-(2-Nitrophenyl)-2-hydroxyacetonitrile; (2-Nitrophenyl)(hydroxy)acetonitrile; 2-Nitrobenzaldehyde cyanohydrin; α-Hydroxy-o-nitrobenzyl cyanide; 2-Hydroxy-2-(2-nitrophenyl)ethanenitrile; o-Nitrobenzaldehyde cyanohydrin; 2-Nitro-mandelonitrile
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-2-(2-Nitrophenyl)Acetonitrile is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (by HPLC), identification (IR), and impurity profiles. Our quality commitment supports your R&D and scale-up processes with reliable, traceable material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.