Description

Z-Ile-Gly-Oh is a protected dipeptide building block featuring a benzyloxycarbonyl (Z) N-terminal protecting group. This compound is a critical intermediate in the synthesis of more complex peptides, offering controlled reactivity for sequential coupling strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide drug discovery and development, where high-purity intermediates are essential for successful synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled, stepwise assembly of peptide chains in both research and production scales.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methodologies for constructing specific peptide sequences or segments.
• Pharmaceutical Intermediate: Serves as a key raw material in the synthesis of potential therapeutic peptides targeting various diseases.
• Biochemical Research: Employed in studies of peptide structure-activity relationships (SAR) and for creating custom peptide substrates or inhibitors.
• Production of Protected Peptide Fragments: Used to generate larger, still-protected peptide segments for convergent synthesis strategies.

Basic Information

Product Name	Z-Ile-Gly-Oh
CAS No.	13254-04-1
Molecular Formula	C₁₇H₂₄N₂O₅
Molecular Weight	336.38 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-L-isoleucylglycine; Z-Ile-Gly-OH; Z-L-Isoleucyl-glycine; Cbz-Ile-Gly-OH; N-Carbobenzoxy-L-isoleucylglycine; Nα-Cbz-L-isoleucylglycine; Benzyl N-[(2S,3S)-1-[(carboxymethyl)amino]-3-methyl-1-oxopentan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Ile-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by spectroscopic methods. We provide Certificates of Analysis (COA) with detailed specifications for traceability and quality assurance, supporting cGMP-compliant applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.