Description

Cyclohexyl Chloroformate is a versatile and highly reactive chloroformate ester, widely used as a key reagent in organic synthesis and pharmaceutical manufacturing. Its primary value lies in its ability to act as a protecting group for alcohols and amines, as well as a versatile intermediate for constructing more complex molecular architectures. This compound is essential for research laboratories and industrial-scale production facilities focused on developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty polymers.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of various active pharmaceutical ingredients (APIs), including carbamate-based drugs and prodrugs.
• Protecting Group Reagent: Used to protect hydroxyl and amino groups during multi-step synthetic sequences, particularly in peptide and nucleotide chemistry.
• Agrochemical Synthesis: Serves as an intermediate in the production of certain herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Employed in the synthesis of specialty polymers, such as polycarbonates and polyurethanes, and as a modifying agent for polymer surfaces.
• Cross-coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions to form carbon-heteroatom bonds.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in exploring new synthetic pathways and optimizing reaction conditions.

Basic Information

Item	Detail
Product Name	Cyclohexyl Chloroformate
CAS No.	13248-54-9
Molecular Formula	C7H11ClO2
Molecular Weight	162.62 g/mol
Synonyms	Cyclohexyloxycarbonyl chloride; Chloroformic acid cyclohexyl ester; Cyclohexyl carbonochloridate; Cyclohexyl chlorocarbonate; Carbonochloridic acid, cyclohexyl ester; Cyclohexyloxycarbonylchloride; Cyclohexyl chloroformiate
EINECS	236-231-6

Quality Control

Our Cyclohexyl Chloroformate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality documentation, including a detailed Certificate of Analysis (COA) for each lot, which confirms identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified for specific grades. Due to its moisture-sensitive and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, strong oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Cyclohexanol Content (GC)	≤ 1.0%
Water Content (Karl Fischer)	≤ 0.1%
Density (at 20°C)	1.10 - 1.15 g/mL
Refractive Index (n20D)	1.450 - 1.455

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.