Description

1,4:3,6-Dianhydro-D-Threo-Hexo-2,5-Diulose is a specialized chiral carbohydrate derivative, also known as isosorbide dinitrate impurity C, which serves as a critical intermediate and reference standard in advanced pharmaceutical synthesis. Its high-purity form is essential for ensuring the quality, safety, and regulatory compliance of cardiovascular and other active pharmaceutical ingredients (APIs). This compound is primarily required by research institutions, analytical laboratories, and fine chemical manufacturers focused on developing and producing high-value pharmaceutical products.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly nitrates and other cardiovascular agents.
• Reference Standard: Used as a certified reference material (CRM) or impurity standard in analytical methods for quality control of APIs like isosorbide dinitrate.
• Process Research & Development: Employed in route scouting and optimization studies within medicinal chemistry and process chemistry groups.
• Academic & Industrial Research: Serves as a substrate or model compound in carbohydrate chemistry research and stereoselective synthesis studies.
• Regulatory Compliance: Essential for method validation and impurity profiling to meet stringent FDA, ICH, and EMA guidelines for drug submissions.

Basic Information

Product Name	1,4:3,6-Dianhydro-D-Threo-Hexo-2,5-Diulose
CAS No.	13241-36-6
Molecular Formula	C6H8O4
Molecular Weight	144.13 g/mol
Synonyms	1,4:3,6-Dianhydro-D-threo-hex-2-ulose-2,5-dione; D-Threo-1,4:3,6-dianhydrohexitol-2,5-dione; Isosorbide Dinitrate Impurity C; 2,5-Diketo-1,4:3,6-dianhydro-D-threo-hexitol; Dianhydro-D-threo-hexodiulose; 1,4:3,6-Dianhydro-2,5-diulose-D-threo-hexitol; D-Isosorbide Dinitrate Related Compound C
EINECS	Contact for details

Quality Control

Our 1,4:3,6-Dianhydro-D-Threo-Hexo-2,5-Diulose is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with ICH Q3A, Q3B, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.