Description

Dimethyl 2-Oxoglutarate is a high-purity diester derivative of α-ketoglutaric acid, serving as a critical biochemical intermediate and building block. Its primary value lies in its role as a cell-permeable precursor to 2-oxoglutarate, a key metabolite in the Krebs cycle and a co-substrate for numerous dioxygenase enzymes. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical sectors, where it is utilized in cell culture media, metabolic studies, and as a starting material for sophisticated organic syntheses.

Application

• Pharmaceutical Intermediate: Key starting material or precursor in the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.
• Cell Culture & Biotechnology: Used as a component in cell culture media to support cellular metabolism, particularly in mammalian cell cultures for bioproduction.
• Biochemical Research: Serves as a substrate or metabolic modulator in studies involving the TCA cycle, hypoxia-inducible factor (HIF) prolyl hydroxylases, and other 2-oxoglutarate-dependent dioxygenases.
• Nutritional Science: Investigated for use in dietary supplements and clinical nutrition products targeting cellular energy metabolism and athletic performance.
• Organic Synthesis: Valuable diester reagent for transesterification reactions and the preparation of more complex keto-acid derivatives.

Basic Information

Product Name	Dimethyl 2-Oxoglutarate
CAS No.	13192-04-6
Molecular Formula	C7H10O5
Molecular Weight	174.15 g/mol
Synonyms	Dimethyl α-Ketoglutarate; 2-Oxopentanedioic Acid Dimethyl Ester; α-Ketoglutaric Acid Dimethyl Ester; Dimethyl Oxoglutarate; DMKG; Dimethyl 2-Oxopentanedioate; 2-Oxoglutaric Acid Dimethyl Ester; Dimethyl Ketoglutarate
EINECS	236-149-5

Quality Control

Our Dimethyl 2-Oxoglutarate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and industrial applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (typically 15-25°C). The product may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.