Description

L-Proline, 4-Hydroxy-1-Methyl-, Methyl Ester, trans- (9Ci) is a specialized, high-purity derivative of the amino acid proline, serving as a critical chiral building block and intermediate in advanced organic synthesis. This compound matters for its precise stereochemistry and functional groups, which enable the construction of complex molecular architectures with high enantiomeric purity. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), peptidomimetics, and other bioactive compounds where structural integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Peptidomimetics Research: Used to construct constrained peptide analogs and protease inhibitors due to its proline-based, hydroxylated structure.
• Asymmetric Catalysis: Serves as a precursor for ligands or organocatalysts in stereoselective chemical transformations.
• Agrochemical Synthesis: Employed in the development of novel, enantiomerically pure herbicides or plant growth regulators.
• Bioconjugation & Probe Development: Utilized in medicinal chemistry for attaching labels or modifying peptides in biochemical probes.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and new reaction development.

Basic Information

Product Name	L-Proline, 4-Hydroxy-1-Methyl-, Methyl Ester, trans- (9Ci)
CAS No.	13135-69-8
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	trans-4-Hydroxy-1-methyl-L-proline methyl ester; Methyl (2S,4R)-4-hydroxy-1-methylpyrrolidine-2-carboxylate; (2S,4R)-1-Methyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester; L-4-Hydroxy-1-methylproline methyl ester; 4-Hydroxy-1-methyl-L-proline methyl ester; Hydroxy-methyl-proline methyl ester; Proline derivative 13135-69-8
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-1-Methyl-, Methyl Ester, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC and structural confirmation by NMR and IR spectroscopy, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.