Description

p-Hydroxymandelonitrile is a versatile aromatic cyanohydrin derivative, serving as a key chiral building block and intermediate in advanced organic synthesis. Its significance lies in its bifunctional structure, featuring both a phenolic hydroxyl and a nitrile group, which enables its use in constructing complex molecular architectures. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of chiral drugs, particularly β-blockers and other cardiovascular or neurological active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides and plant growth regulators, leveraging its cyanohydrin functionality.
• Fine Chemical Building Block: Employed in asymmetric synthesis and catalysis for creating high-value specialty chemicals and flavors/fragrances.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies related to hydroxynitrile lyases and other enzymes.
• Material Science: A monomer or cross-linking agent in the development of specialty polymers and resins.

Basic Information

Product Name	p-Hydroxymandelonitrile
CAS No.	13093-65-7
Molecular Formula	C8H7NO2
Molecular Weight	149.15 g/mol
Synonyms	4-Hydroxymandelonitrile; (4-Hydroxyphenyl)(hydroxy)acetonitrile; 4-Hydroxybenzaldehyde cyanohydrin; p-Hydroxybenzaldehyde cyanohydrin; 2-Hydroxy-2-(4-hydroxyphenyl)acetonitrile; Mandelonitrile, 4-hydroxy-; 4-Hydroxy-α-(hydroxymethyl)benzenacetonitrile
EINECS	Contact for details

Quality Control

Our p-Hydroxymandelonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.