Description

Isosorbide-2-Acetate is a high-purity, functionalized derivative of isosorbide, a bio-based platform chemical derived from renewable resources. This compound is valued for its role as a key chiral intermediate and building block in advanced organic synthesis, offering a sustainable alternative to petrochemical-derived intermediates. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty polymer sectors for developing novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in cardiovascular and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Serves as a building block for creating advanced, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Used as a monomer or co-monomer to introduce rigidity and biodegradability into polyesters, polycarbonates, and polyurethanes.
• Liquid Crystal & OLED Materials: Acts as a core structure for developing chiral dopants and charge-transport materials in display and lighting technologies.
• Cosmetic & Personal Care Ingredients: Employed in the synthesis of specialty esters and surfactants with enhanced skin feel and environmental profiles.
• Crosslinking Agent: Functions as a crosslinker in resin formulations to improve thermal stability and mechanical properties.
• Chemical Research & Development: A versatile reagent for asymmetric synthesis and methodology development in academic and industrial R&D laboratories.

Basic Information

Product Name	Isosorbide-2-Acetate
CAS No.	13042-39-2
Molecular Formula	C8H10O5
Molecular Weight	186.16 g/mol
Synonyms	1,4:3,6-Dianhydro-D-glucitol 2-acetate; 2-O-Acetyl-1,4:3,6-dianhydro-D-glucitol; Isosorbide 2-monoacetate; D-Isosorbide 2-acetate; 1,4:3,6-Dianhydro-D-sorbitol 2-acetate; 2-Acetoxy-1,4:3,6-dianhydro-D-glucitol; (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diyl diacetate (related diacetate); Dianhydrosorbitol 2-acetate
EINECS	Contact for details

Quality Control

Our Isosorbide-2-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for sensitive synthetic applications. We provide detailed Certificates of Analysis (COA) with each shipment, documenting key parameters such as assay, enantiomeric excess, and impurity profiles. Specifications can be aligned with cGMP, ICH Q7, or other relevant pharmaceutical guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.