Description

2,3:4,5-Di-o-Isopropylidene-D-Xylose is a protected sugar derivative, specifically a diacetonide of D-xylose, widely recognized by its CAS number 13039-94-6. This compound serves as a crucial chiral building block and synthetic intermediate in advanced organic synthesis, offering a locked furanose ring structure that is resistant to unwanted side reactions. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of nucleoside analogs, carbohydrate-based therapeutics, and complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Carbohydrate Chemistry: Used as a protected starting material for the stereoselective synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for creating libraries of novel bioactive compounds targeting various diseases.
• Process Development: Employed in scaling up routes to chiral molecules where the isopropylidene protecting groups provide stability during multi-step syntheses.
• Academic & Industrial R&D: A standard reagent for studying glycosylation reactions, ring-opening transformations, and the synthesis of labeled sugars for metabolic studies.

Basic Information

Product Name	2,3:4,5-Di-o-Isopropylidene-D-Xylose
CAS No.	13039-94-6
Molecular Formula	C11H18O5
Molecular Weight	230.26 g/mol
Synonyms	1,2:3,4-Di-O-isopropylidene-D-xylose; D-Xylose Diacetonide; 1,2:3,4-Di-O-isopropylidene-α-D-xylofuranose; 2,3:4,5-Di-O-isopropylidene-D-xylofuranose; Diacetone-D-xylose; D-Xylose Diacetone Derivative; 1,2:3,4-Di-O-(1-methylethylidene)-α-D-xylofuranose; 13039-94-6
EINECS	235-903-1

Quality Control

Our 2,3:4,5-Di-o-Isopropylidene-D-Xylose is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-70° to -75° (c=1 in CHCl3)
Melting Point	95°C - 100°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.