Description

(Z)-3-(3,4-Dihydro-2H-Pyrrole-5-Yl)-2-Hydroxypropenamide is a specialized heterocyclic building block featuring a dihydropyrrole core linked to a hydroxypropenamide moiety. This compound matters as a key chiral intermediate in the synthesis of complex pharmaceutical molecules, offering a versatile scaffold for medicinal chemistry and drug discovery research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs targeting various diseases.
• Agrochemical Synthesis: Acts as a precursor in the development of advanced crop protection agents and pesticides.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and performance materials.
• Bioconjugation & Probe Development: The reactive amide and hydroxyl groups make it suitable for creating biochemical probes and conjugation linkers.

Basic Information

Product Name	(Z)-3-(3,4-Dihydro-2H-Pyrrole-5-Yl)-2-Hydroxypropenamide
CAS No.	12688-72-1
Molecular Formula	C7H10N2O2
Molecular Weight	154.17 g/mol
Synonyms	(Z)-3-(3,4-Dihydro-2H-pyrrol-5-yl)-2-hydroxyacrylamide; 2-Hydroxy-3-(3,4-dihydro-2H-pyrrol-5-yl)propenamide; 5-(1-Carbamoyl-2-hydroxyvinyl)-3,4-dihydro-2H-pyrrole; (Z)-3-(3,4-Dihydro-2H-pyrrol-5-yl)-2-hydroxy-2-propenamide; 12688-72-1; 3-(3,4-Dihydro-2H-pyrrol-5-yl)-2-hydroxyacrylamide (Z-isomer)
EINECS	Contact for details

Quality Control

Our (Z)-3-(3,4-Dihydro-2H-Pyrrole-5-Yl)-2-Hydroxypropenamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from advanced techniques like HPLC, NMR, and MS. Our quality commitment supports cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.