Description

3-O,5-o-Bis(Trimethylsilyl)-2-Deoxy-D-Ribo-Pentonic Acid γ-Lactone is a key protected intermediate in synthetic organic chemistry, particularly valued for its role in nucleoside and carbohydrate synthesis. Its primary commercial value lies in providing a versatile, silyl-protected scaffold that enables precise and efficient construction of complex bioactive molecules. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity building blocks for advanced synthesis.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of modified nucleosides, nucleotides, and antiviral/anticancer drug candidates.
• Carbohydrate Chemistry: Serves as a protected precursor for the preparation of complex sugars, glycoconjugates, and glycomimetics.
• Oligonucleotide Synthesis: Used in the research and development of antisense oligonucleotides and other therapeutic nucleic acids.
• Fine Chemical Synthesis: A versatile chiral synthon for constructing natural products and other high-value specialty chemicals.
• Academic & Industrial R&D: Employed in methodological development and exploratory synthesis within medicinal chemistry and chemical biology.
• Agrochemical Research: Potential intermediate in the development of novel active ingredients with specific biological activity.

Basic Information

Product Name	3-O,5-o-Bis(Trimethylsilyl)-2-Deoxy-D-Ribo-Pentonic Acid γ-Lactone
CAS No.	10589-33-0
Molecular Formula	C14H30O4Si2
Molecular Weight	318.56 g/mol
Synonyms	2-Deoxy-D-ribono-1,4-lactone 3,5-bis-O-(trimethylsilyl) ether; 3,5-Bis-O-(trimethylsilyl)-2-deoxy-D-ribono-1,4-lactone; 3,5-Di-O-trimethylsilyl-2-deoxy-D-ribono-1,4-lactone; 2-Deoxy-3,5-di-O-trimethylsilyl-D-ribono-1,4-lactone; D-Ribonic acid, 2-deoxy-, γ-lactone, 3,5-bis-O-(trimethylsilyl)-; Protected 2-deoxyribonolactone; TMS-protected deoxyribonolactone
EINECS	Contact for details

Quality Control

Our 3-O,5-o-Bis(Trimethylsilyl)-2-Deoxy-D-Ribo-Pentonic Acid γ-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.