Description

3-Bromo-5-Phenyl-Isoxazole is a versatile heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and functional materials, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the isoxazole ring's bioactivity.
• Material Science Research: Acts as a building block for creating advanced organic materials, such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and protein functions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to introduce the 5-phenylisoxazole moiety into more complex molecules.
• Ligand Synthesis: Utilized for the preparation of specialized ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	3-Bromo-5-Phenyl-Isoxazole
CAS No.	10557-74-1
Molecular Formula	C9H6BrNO
Molecular Weight	224.06 g/mol
Synonyms	3-Bromo-5-phenyl-1,2-oxazole; 5-Phenyl-3-bromoisoxazole; 3-Bromo-5-phenylisoxazole; Isoxazole, 3-bromo-5-phenyl-; 1,2-Oxazole, 3-bromo-5-phenyl-; NSC 163082
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Phenyl-Isoxazole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We are committed to meeting the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.