Description

Ethyl 4-Chloro-3-hydroxybutyrate is a versatile chiral building block and synthetic intermediate of significant importance in fine chemical synthesis. Its value lies in the presence of multiple functional groups—a chloro, a hydroxyl, and an ester—which allow for selective transformations, making it a key precursor for pharmaceuticals and other high-value compounds. This product is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of statin drugs (e.g., Atorvastatin, Rosuvastatin) and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that require specific stereochemistry for efficacy.
• Fine Chemical Production: Serves as a starting material for fragrances, flavors, and other specialty organic compounds.
• Biochemical Research: Employed in enzymatic studies and as a substrate for investigating metabolic pathways.
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialized polymers and resins.
• Asymmetric Synthesis: A valuable substrate for catalytic asymmetric reactions to produce enantiomerically pure compounds.

Basic Information

Product Name	Ethyl 4-Chloro-3-hydroxybutyrate
CAS No.	10488-69-4
Molecular Formula	C6H11ClO3
Molecular Weight	166.60 g/mol
Synonyms	Ethyl 4-chloro-3-hydroxybutanoate; 4-Chloro-3-hydroxybutyric acid ethyl ester; (R/S)-Ethyl 4-chloro-3-hydroxybutyrate; 3-Hydroxy-4-chlorobutyric acid ethyl ester; Ethyl 4-chloro-3-hydroxybutyrate; Ethyl γ-chloro-β-hydroxybutyrate; 10488-69-4; Butyric acid, 4-chloro-3-hydroxy-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-3-hydroxybutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (R or S isomer as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Provided on COA
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.