Description

Ethyl 2-Acetyl-4-Cyanobutyrate is a versatile bifunctional ester and nitrile compound, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both an active methylene ketone and a cyano group, makes it a valuable precursor for constructing complex heterocycles and pharmaceutical intermediates. This high-purity chemical is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-quality raw materials for scalable synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing pyrrolidine, piperidine, or other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging its reactivity to form specific bioactive scaffolds.
• Fine Chemical Production: Serves as a building block for dyes, pigments, and specialty polymers where specific functional group compatibility is required.
• Research & Development: A valuable reagent in academic and industrial R&D for method development and exploring new synthetic routes to complex molecules.
• Chemical Synthesis: Employed in Knoevenagel condensations, Michael additions, and cyclization reactions to create novel carbon chains and ring systems.

Basic Information

Product Name	Ethyl 2-Acetyl-4-Cyanobutyrate
CAS No.	10444-33-4
Molecular Formula	C9H13NO3
Molecular Weight	183.21 g/mol
Synonyms	Ethyl 2-acetyl-4-cyanobutanoate; 4-Cyano-2-oxo-hexanoic acid ethyl ester; 2-Acetyl-4-cyanobutyric acid ethyl ester; Ethyl 4-cyano-2-oxohexanoate; 4-Cyano-2-oxohexanoic Acid Ethyl Ester; Butanoic acid, 2-acetyl-4-cyano-, ethyl ester; Ethyl α-acetyl-γ-cyanobutyrate
EINECS	233-943-7

Quality Control

Every batch of Ethyl 2-Acetyl-4-Cyanobutyrate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.