Description

5-(Hydroxymethyl)Dihydrofuran-2(3H)-One is a versatile lactone derivative and a valuable chiral building block in organic synthesis. Its structure, featuring both a hydroxymethyl group and a lactone ring, makes it a critical intermediate for constructing complex molecules with high stereochemical control. This compound is essential for research and production in the pharmaceutical and fine chemical industries, where it is used to synthesize active pharmaceutical ingredients (APIs), nucleoside analogs, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of nucleoside-based antiviral and anticancer drugs.
• Fine Chemical Synthesis: Used in the production of complex natural products, flavors, and fragrances requiring specific stereochemistry.
• Agrochemical Research: Serves as a building block for developing novel, high-efficacy crop protection agents.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating biodegradable or functional polymers.
• Academic & R&D: A valuable reagent in medicinal chemistry and process development research for exploring new synthetic routes.
• Cosmetic Ingredients: Potential intermediate for synthesizing specialty esters and other functional ingredients.

Basic Information

Product Name	5-(Hydroxymethyl)Dihydrofuran-2(3H)-One
CAS No.	10374-51-3
Molecular Formula	C5H8O3
Molecular Weight	116.12 g/mol
Synonyms	5-(Hydroxymethyl)dihydro-2(3H)-furanone; (R)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one; (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one; γ-Hydroxymethyl-γ-butyrolactone; Tetrahydro-5-(hydroxymethyl)-2-furanone; 5-Hydroxymethyl butyrolactone; (R)-(-)-5-(Hydroxymethyl)-2(3H)-furanone
EINECS	233-826-9

Quality Control

We supply 5-(Hydroxymethyl)Dihydrofuran-2(3H)-One in various purity grades, including standard and high-purity (≥98%) material suitable for research and commercial synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, enantiomeric excess (where applicable), and impurity profiles are available upon request. We adhere to cGMP principles for production relevant to pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Purity (Chiral HPLC)	Specify: Racemic, (R)-, or (S)- Enantiomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.