Description

trans-4-(Pyrrolidin-1-yl)tetrahydrofuran-3-ol is a versatile chiral building block and heterocyclic compound of significant interest in advanced organic synthesis. Its unique structure, featuring both pyrrolidine and tetrahydrofuran rings with a hydroxyl group, makes it a valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and receptor modulators.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides that require specific stereochemistry for optimal activity.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-oxygen containing ligands used in asymmetric catalysis and metal complexation.
• Academic and R&D Laboratories: Employed in methodological studies and the synthesis of complex natural product analogs or novel heterocyclic libraries.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals for electronics, materials science, and performance additives.

Basic Information

Product Name	trans-4-(Pyrrolidin-1-yl)tetrahydrofuran-3-ol
CAS No.	10295-95-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	trans-4-(1-Pyrrolidinyl)tetrahydro-3-furanol; 3-Hydroxy-4-(pyrrolidin-1-yl)tetrahydrofuran (trans); 4-(Pyrrolidin-1-yl)tetrahydrofuran-3-ol; THF derivative with pyrrolidine; Pyrrolidinyl tetrahydrofuranol; Chiral pyrrolidine-THF alcohol; 1-(3-Hydroxytetrahydrofuran-4-yl)pyrrolidine; 10295-95-1
EINECS	Contact for details

Quality Control

Our trans-4-(Pyrrolidin-1-yl)tetrahydrofuran-3-ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.