Description

(4Ar,5R)-4,4A,5,6-Tetrahydro-4A,5-Dimethyl-6-Oxonaphtho[2,3-B]Furan-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring structure. This compound is valued for its role as a key chiral building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those with naphthofuran or related polycyclic frameworks.
• Medicinal Chemistry Research: Used as a chiral scaffold for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents.
• Organic Synthesis Building Block: Serves as a versatile starting material for constructing complex natural product analogs and other specialty organic compounds.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target molecules in fine chemical and pharmaceutical manufacturing.
• Academic Research: Utilized in university and institutional laboratories for studies in asymmetric synthesis, heterocyclic chemistry, and methodology development.

Basic Information

Item	Detail
Product Name	(4Ar,5R)-4,4A,5,6-Tetrahydro-4A,5-Dimethyl-6-Oxonaphtho[2,3-B]Furan-3-Carboxylic Acid Methyl Ester
CAS No.	10208-62-5
Molecular Formula	C₁₇H₁₈O₅
Molecular Weight	302.32 g/mol
Synonyms	Methyl (4aR,5R)-4a,5-dimethyl-6-oxo-4a,5,6,7-tetrahydro-4H-naphtho[2,3-b]furan-3-carboxylate; (4aR,5R)-4a,5-Dimethyl-6-oxo-4a,5,6,7-tetrahydro-4H-naphtho[2,3-b]furan-3-carboxylic acid methyl ester; 4a,5,6,7-Tetrahydro-4a,5-dimethyl-6-oxonaphtho[2,3-b]furan-3-carboxylic acid methyl ester, (4aR,5R)-; Naphtho[2,3-b]furan-3-carboxylic acid, 4,4a,5,6-tetrahydro-4a,5-dimethyl-6-oxo-, methyl ester, (4aR,5R)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support development projects with custom synthesis and scale-up services, maintaining traceability and consistency from gram to kilogram quantities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.