Description

(1R,8Aβ)-7β-Ethynyl-4A,5,6,7,8,8A-Hexahydro-1,4Aβ-Dimethylnaphthalen-2(1H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex decalin ring structure and ethynyl functional group. This compound matters as a critical building block in the synthesis of novel steroid-based therapeutics and fine chemicals, offering a precise chiral scaffold for further molecular elaboration. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly in the areas of hormone modulators and anti-inflammatory agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel steroid analogs and hormone receptor modulators.
• Organic Synthesis Building Block: Utilized in complex organic transformations, including cycloadditions and cross-coupling reactions, leveraging its ethynyl group.
• Medicinal Chemistry Research: Employed in drug discovery programs for the development of new anti-inflammatory and anticancer agents.
• Fine Chemical Production: Used in the manufacture of high-value specialty chemicals requiring a defined stereochemical configuration.
• Academic & R&D Laboratories: Acts as a reference standard and starting material for methodological studies in synthetic organic chemistry.

Basic Information

Product Name	(1R,8Aβ)-7β-Ethynyl-4A,5,6,7,8,8A-Hexahydro-1,4Aβ-Dimethylnaphthalen-2(1H)-One
CAS No.	10208-55-6
Molecular Formula	C₁₄H₁₈O
Molecular Weight	202.29 g/mol
Synonyms	7β-Ethynyl-4a,5,6,7,8,8a-hexahydro-1,4aβ-dimethylnaphthalen-2(1H)-one; (1R,4aS,8aS)-7-Ethynyl-1,4a-dimethyl-4,4a,5,6,7,8,8a,9-octahydro-2H-naphthalen-2-one; 7β-Ethynyl-1,4aβ-dimethyl-4,4a,5,6,7,8,8a,9-octahydro-2H-naphthalen-2-one; 7-Ethynyl-1,4a-dimethyl-4,4a,5,6,7,8,8a,9-octahydro-2H-naphthalen-2-one; 7β-Ethynyl-1,4a-dimethyl-4,4a,5,6,7,8,8a,9-octahydro-2H-naphthalen-2-one; 7-Ethynyl-1,4a-dimethyl-4,4a,5,6,7,8,8a,9-octahydro-2H-naphthalen-2-one (1R,4aS,8aS)-; 7β-Ethynyl-4a,5,6,7,8,8a-hexahydro-1,4aβ-dimethylnaphthalen-2(1H)-one
EINECS	Contact for details

Quality Control

Our (1R,8Aβ)-7β-Ethynyl-4A,5,6,7,8,8A-Hexahydro-1,4Aβ-Dimethylnaphthalen-2(1H)-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and related substances are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.