Description

(S)-(+)-2-Methylglutaric Acid Dimethyl Ester is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its defined stereochemistry makes it a critical precursor for the production of enantiomerically pure pharmaceuticals, agrochemicals, and fine chemicals. This compound is essential for research and development chemists and process chemists in the pharmaceutical, biotechnology, and specialty chemical industries seeking to introduce specific chiral centers into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a specific (S)-configuration for biological activity.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators where stereochemistry impacts efficacy and environmental profile.
• Fine Chemical & Flavor/Fragrance Precursor: Serves as a building block for creating complex, high-value odorants and flavoring agents with specific sensory properties.
• Ligand & Catalyst Development: Employed in academic and industrial research for the synthesis of chiral ligands, organocatalysts, and metal-organic frameworks (MOFs).
• Polymer Chemistry: Can be utilized as a monomer or co-monomer for producing specialized polyesters with tailored properties.
• Asymmetric Synthesis: A versatile starting material for a wide range of asymmetric transformations, including alkylations, reductions, and cross-coupling reactions.

Basic Information

Product Name	(S)-(+)-2-Methylglutaric Acid Dimethyl Ester
CAS No.	10171-92-3
Molecular Formula	C9H16O4
Molecular Weight	188.22 g/mol
Synonyms	(S)-(+)-Dimethyl 2-Methylglutarate; (S)-2-Methylpentanedioic Acid Dimethyl Ester; (S)-(+)-2-Methylpentanedioic Acid Dimethyl Ester; Dimethyl (S)-2-Methylglutarate; (S)-1,5-Dimethoxy-1,5-dioxopentan-2-ane; (S)-Methyl hydrogen 2-methylglutarate (common misnomer); (S)-2-Methylglutaric Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our (S)-(+)-2-Methylglutaric Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC or GC, to ensure high enantiomeric excess (e.e.) and chemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is moisture-sensitive; ensure containers are sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 99.0% e.e.
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.