Description

Ethyl (2E)-4-Hydroxy-But-2-Enoate is a high-purity, unsaturated ester compound that serves as a versatile chiral building block in advanced organic synthesis. Its bifunctional nature, featuring both a hydroxyl group and an α,β-unsaturated ester moiety, makes it a critical intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty fine chemical industries, where it is used to develop active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of prostaglandins, antiviral agents, and other bioactive molecules requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its reactivity for creating complex side chains.
• Fine Chemical Production: Serves as a precursor for flavors, fragrances, and specialty polymers where its unsaturated ester functionality is utilized.
• Academic & R&D: A valuable reagent in medicinal chemistry and process development research for exploring new synthetic pathways.
• Cross-Coupling Reactions: Acts as an electrophilic partner in Michael additions and other conjugate addition reactions to form carbon-carbon bonds.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to produce enantiomerically enriched compounds for high-value applications.

Basic Information

Product Name	Ethyl (2E)-4-Hydroxy-But-2-Enoate
CAS No.	10080-68-9
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	(2E)-4-Hydroxybut-2-enoic Acid Ethyl Ester; Ethyl (E)-4-Hydroxy-2-butenoate; Ethyl 4-Hydroxycrotonate; (E)-Ethyl 4-Hydroxy-2-butenoate; 4-Hydroxy-2-butenoic Acid Ethyl Ester, (E)-; trans-4-Hydroxycrotonic Acid Ethyl Ester; 2-Butenoic Acid, 4-Hydroxy-, Ethyl Ester, (2E)-
EINECS	233-215-6

Quality Control

Our Ethyl (2E)-4-Hydroxy-But-2-Enoate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral purity, GC for residual solvents, and spectroscopic identification (IR, NMR), to ensure it meets stringent specifications for research and industrial use. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (if applicable)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.