Description

(R)-(+)-4-Methylmandelonitrile is a high-purity chiral nitrile compound, serving as a critical intermediate in asymmetric synthesis. Its value lies in providing the enantiomerically pure (R)-configuration, which is essential for producing optically active pharmaceuticals and agrochemicals. This product is primarily needed by research institutions and manufacturers in the pharmaceutical, fine chemical, and agrochemical industries for developing chiral active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of enantiomerically pure drugs, particularly in cardiovascular and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry is required for optimal biological activity and environmental safety.
• Fine Chemical Production: Employed in asymmetric synthesis for creating complex, high-value specialty chemicals and flavors & fragrances.
• Academic & Industrial Research: Serves as a standard or starting material in methodological development for new catalytic asymmetric reactions and chiral pool syntheses.
• Ligand and Catalyst Preparation: Utilized as a precursor for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.

Basic Information

Product Name	(R)-(+)-4-Methylmandelonitrile
CAS No.	10017-04-6
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	(R)-(+)-4-Methylmandelonitrile; (R)-4-Methylmandelonitrile; (R)-α-Hydroxy-4-methylbenzeneacetonitrile; (R)-(+)-α-Hydroxy-p-toluonitrile; (R)-p-Methylmandelonitrile; (R)-4-Methylbenzaldehyde cyanohydrin; (R)-Cyanohydrin of 4-methylbenzaldehyde; (R)-O-Methylmandelonitrile (less common)
EINECS	233-015-9

Quality Control

Our (R)-(+)-4-Methylmandelonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.