Description

2α-Bromo-5α-Cholestan-3-One Ethylene Acetal CAS NO 1923-43-9 is a high-purity, synthetic steroid intermediate characterized by its brominated cholestane backbone protected as an ethylene acetal. This compound is a critical building block in the synthesis of complex steroid molecules and vitamin D analogs, offering precise control over stereochemistry and functional group manipulation. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in advanced organic synthesis, medicinal chemistry research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and hormone analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new drug candidates targeting nuclear receptors.
• Vitamin D Analog Synthesis: Serves as a crucial starting material or intermediate in the production of calcitriol derivatives and other secosteroids.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing chiral, polycyclic frameworks due to its defined stereochemistry.
• Biochemical Probe Development: Utilized in the creation of labeled or modified steroid probes for studying metabolic pathways and biological mechanisms.

Basic Information

Product Name	2α-Bromo-5α-Cholestan-3-One Ethylene Acetal
CAS No.	1923-43-9
Molecular Formula	C₂₉H₄₉BrO₂
Molecular Weight	509.61 g/mol
Synonyms	2α-Bromo-5α-cholestan-3-one ethylene ketal; 2α-Bromocholestan-3-one ethylene acetal; (3R,5S,8R,9S,10S,13R,14S,17R)-2-Bromo-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-one ethylene acetal; 5α-Cholestan-3-one, 2α-bromo-, ethylene acetal; 2-Bromo-5α-cholestan-3β-ol ethylene acetal derivative
EINECS	Contact for details

Quality Control

Our 2α-Bromo-5α-Cholestan-3-One Ethylene Acetal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.