Description

3-Chloropyridine n-Oxide is a versatile heterocyclic building block and a key intermediate in organic synthesis. Its value lies in its reactive chlorinated pyridine oxide structure, which facilitates a range of chemical transformations, including nucleophilic substitutions and metal-catalyzed cross-couplings. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing functionalized pyridine motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, insecticides, and fungicides, leveraging its halogenated heterocycle for bioactivity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis and coordination chemistry.
• Material Science Research: Employed in the creation of novel organic compounds and polymers with specific electronic or photophysical properties.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Functional Group Transformation: Utilized for the introduction of oxygen and chlorine functionalities into molecular scaffolds for further derivatization.

Basic Information

Product Name	3-Chloropyridine n-Oxide
CAS No.	1851-22-5
Molecular Formula	C5H4ClNO
Molecular Weight	129.54 g/mol
Synonyms	3-Chloropyridine 1-Oxide; 3-Chloropyridine N-Oxide; 3-Chloro-1-oxidopyridin-1-ium; Pyridine, 3-chloro-, 1-oxide; 3-Chloropyridinium-1-olate; 3-Chloropyridine oxide; 3-CPO
EINECS	217-437-6

Quality Control

Our 3-Chloropyridine n-Oxide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.