Description

(4R)-4β-Hydroxy-1-(Trifluoroacetyl)-L-Proline Methyl Ester is a high-value, chiral proline derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its primary commercial value lies in its role as a key building block for the production of complex pharmaceutical compounds, particularly protease inhibitors and other active pharmaceutical ingredients (APIs). This compound is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and scale-up of novel therapeutics, where precise stereochemistry and high purity are non-negotiable requirements.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of protease inhibitors and other complex APIs.
• Peptidomimetics Research: Used in medicinal chemistry for constructing proline-based scaffolds to mimic peptide structures and modulate biological activity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Fine Chemical Production: Serves as a precursor for other specialty fluorinated and functionalized proline derivatives.
• Bioconjugation Chemistry: The reactive ester and protected amine functionalities make it useful for designing linkers in bioconjugation strategies.
• Academic & R&D: Utilized in university and industrial research laboratories for developing new synthetic methodologies and exploring structure-activity relationships.

Basic Information

Product Name	(4R)-4β-Hydroxy-1-(Trifluoroacetyl)-L-Proline Methyl Ester
CAS No.	1840-28-4
Molecular Formula	C8H10F3NO4
Molecular Weight	241.17 g/mol
Synonyms	L-Proline, 4-hydroxy-1-[(trifluoroacetyl)-, methyl ester, (4R)-; Methyl (4R)-4-hydroxy-1-(trifluoroacetyl)-L-prolinate; (4R)-4-Hydroxy-1-(trifluoroacetyl)-L-proline methyl ester; (R)-4-Hydroxy-1-(trifluoroacetyl)pyrrolidine-2-carboxylic acid methyl ester; (4R)-HTP; Trifluoroacetyl-4-hydroxy-L-proline methyl ester; 4(R)-Hydroxy-1-trifluoroacetyl-L-proline methyl ester
EINECS	Contact for details

Quality Control

Our (4R)-4β-Hydroxy-1-(Trifluoroacetyl)-L-Proline Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.