Description

2,2,2-Trifluoro-1-(4-Hydroxy-Phenyl)-Ethanone is a high-purity trifluoromethyl ketone derivative, a key fluorinated building block prized for its ability to impart unique physicochemical properties to advanced molecules. Its value lies in enabling the synthesis of complex agrochemicals, pharmaceuticals, and specialty materials with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced material sectors seeking to innovate with fluorine chemistry.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl ketone or phenol moiety for bioactivity.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances compound efficacy and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a key fluorinated building block for electronic chemicals used in display and lighting technologies.
• Polymer & Resin Modifier: Incorporated to create specialty polymers with improved chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Employed in academic and industrial research for Friedel-Crafts acylation and other reactions to introduce fluorinated aromatic ketone structures.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed coupling reactions for constructing complex biaryl systems.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-Hydroxy-Phenyl)-Ethanone
CAS No.	1823-63-8
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	4'-Hydroxy-2,2,2-trifluoroacetophenone; 1-(4-Hydroxyphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-4'-hydroxyacetophenone; 4-Hydroxyphenyl trifluoromethyl ketone; p-Hydroxyphenyl trifluoromethyl ketone; Trifluoro(4-hydroxyphenyl)methanone; 4-Acetylphenyl trifluoromethyl ether (common misnomer); TFAP-OH
EINECS	217-356-8

Quality Control

Our 2,2,2-Trifluoro-1-(4-Hydroxy-Phenyl)-Ethanone is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency meet the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	92°C - 96°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.