Description

4-Aminocyclohexanecarboxylic Acid is a versatile chiral building block and a key intermediate in organic synthesis. This compound matters for its rigid cyclohexane backbone and bifunctional amino and carboxylic acid groups, enabling the construction of complex molecular architectures with precise stereochemistry. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), peptidomimetics, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Peptidomimetics & Conformationally Restricted Peptides: Used to introduce constrained cyclohexane rings into peptide backbones to enhance metabolic stability and receptor selectivity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Advanced Material Science: Employed in the synthesis of specialty polymers and dendrimers with tailored properties.
• Agrochemical Research: Utilized as a building block for developing new crop protection agents with specific stereochemical requirements.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	4-Aminocyclohexanecarboxylic Acid
CAS No.	1776-53-0
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	trans-4-Aminocyclohexanecarboxylic Acid; 4-Amino-1-cyclohexanecarboxylic Acid; 4-Aminocyclohexane-1-carboxylic Acid; cis/trans-4-Aminocyclohexanecarboxylic Acid; 4-ACCA; 4-Amino-CHCA; 1-Carboxy-4-aminocyclohexane; 4-Aminocyclohexylcarboxylic Acid
EINECS	217-208-1

Quality Control

Our 4-Aminocyclohexanecarboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess (if applicable), and impurity profiles is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Specify cis/trans or enantiomeric ratio
Loss on Drying	≤ 1.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.