Description

3-(4-Fluorophenyl)-1,1,1-Trifluoro-2-Propanone is a high-purity fluorinated aromatic ketone building block, essential for synthesizing complex molecules with enhanced biological activity and stability. Its trifluoromethyl ketone moiety and fluorinated aromatic ring make it a critical intermediate in the development of advanced pharmaceuticals and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of enzyme inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved metabolic stability and lipophilicity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	3-(4-Fluorophenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	1735-92-8
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	4'-Fluoro-1,1,1-trifluoroacetophenone; 4-Fluorophenyl Trifluoromethyl Ketone; 1-(4-Fluorophenyl)-2,2,2-trifluoroethanone; p-Fluorophenyl Trifluoromethyl Ketone; 4-Fluorobenzoyltrifluoromethane; α,α,α-Trifluoro-4'-fluoroacetophenone; 4-Fluoro-α,α,α-trifluoroacetophenone; 1735-92-8
EINECS	217-079-8

Quality Control

Our 3-(4-Fluorophenyl)-1,1,1-Trifluoro-2-Propanone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF Titration)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.