Description

1-Bromo-2,3,5,6-Tetramethylbenzene is a high-purity, multi-substituted aromatic bromine compound that serves as a versatile and valuable synthetic intermediate. Its sterically hindered structure and bromine functionality make it a critical building block for introducing the tetramethylphenyl group into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-quality intermediates for synthesis and development.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating sterically demanding ligands and complex organic molecules.
• Agrochemical Synthesis: Serves as a key precursor in the development of advanced pesticides and herbicides where the tetramethylbenzene moiety imparts specific biological activity and stability.
• Ligand and Catalyst Preparation: Employed in organometallic chemistry to synthesize phosphine and other donor ligands for homogeneous catalysis.
• Advanced Material Research: Acts as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A valuable reagent for organic synthesis in academic and industrial R&D labs for constructing complex, multi-substituted aromatic systems.
• Fine Chemical Production: Utilized in the custom synthesis of dyes, pigments, and other performance chemicals requiring specific aromatic substitution patterns.

Basic Information

Product Name	1-Bromo-2,3,5,6-Tetramethylbenzene
CAS No.	1646-53-3
Molecular Formula	C10H13Br
Molecular Weight	213.12 g/mol
Synonyms	2,3,5,6-Tetramethylbromobenzene; Pentamethylbromobenzene (historical); Bromodurene; 1-Bromo-2,3,5,6-tetramethyl-benzene; Benzene, 1-bromo-2,3,5,6-tetramethyl-; NSC 404087; Durene, 1-bromo-; Bromopentamethylbenzene (common name)
EINECS	216-713-9

Quality Control

Our 1-Bromo-2,3,5,6-Tetramethylbenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with your specifications. Our commitment to quality ensures a reliable supply of this high-value intermediate for your critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and strong oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Melting Point	95°C - 99°C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.