Description

3-tert-Butyldiazirine is a specialized diazirine derivative, a class of compounds valued for their ability to generate highly reactive carbene intermediates upon photochemical or thermal activation. This compound is particularly significant as a versatile photoaffinity labeling reagent and crosslinking agent in advanced chemical biology and materials science research. It is essential for researchers and industrial chemists in pharmaceuticals, proteomics, and polymer chemistry who require precise, covalent modification of biomolecules or polymer matrices.

Application

• Photoaffinity Labeling (PAL): A critical tool in chemical biology and drug discovery for mapping small molecule-protein interactions and identifying biological targets.
• Bioconjugation & Crosslinking: Used to create stable covalent bonds between biomolecules (e.g., proteins, nucleic acids) and probes, surfaces, or other molecules.
• Polymer Surface Modification: Enables the functionalization of polymer surfaces to alter wettability, adhesion, or biocompatibility for advanced materials.
• Proteomics Research: Facilitates the study of protein structures, dynamics, and interactions through site-specific labeling strategies.
• Ligand-Directed Chemistry: Serves as a key reagent in developing targeted covalent inhibitors and therapeutic agents.
• Materials Science: Employed in the synthesis and crosslinking of specialty polymers and functional materials requiring precise spatial control.

Basic Information

Product Name	3-tert-Butyldiazirine
CAS No.	1630-93-9
Molecular Formula	C6H12N2
Molecular Weight	112.18 g/mol
Synonyms	3-(tert-Butyl)diazirine; tert-Butyldiazirine; 3-(1,1-Dimethylethyl)diazirine; Diaziridine, 3-(1,1-dimethylethyl)-; 3-tert-Butyl-diaziridine; Photoaffinity Labeling Reagent; PAL Reagent
EINECS	Contact for details

Quality Control

Our production of 3-tert-Butyldiazirine adheres to stringent quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and light-sensitive nature, store the product in a cool (2-8°C), dry, and well-ventilated place, preferably under an inert atmosphere for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.